Rejuran Injection (Salmon DNA / PN)

Rejuran Injection in Seoul

Medically reviewed by Dr. Chae-ho Lee, Medical Director, Doctorpetit Clinic Hongdae; Member, Korean Society of Clinical Aesthetic Medicine

Doctor profile · Doctorpetit Clinic Hongdae, Seoul

Rejuran injection in Seoul is a skin-regeneration treatment in which polynucleotide (PN), a substance derived from salmon DNA, is injected in small amounts into the skin to support its own repair processes. At Doctorpetit Clinic Hongdae, the goal is better elasticity, softer fine wrinkles, and smoother texture rather than any change to facial shape. The injection itself takes roughly 15 to 30 minutes, and most people go back to their day straight afterward.

What Is Rejuran Injection?

Rejuran injection is a minimally invasive skin booster that delivers salmon-DNA-derived polynucleotide into the skin to help it repair itself, strengthen elasticity, and refine texture over a course of sessions.

• The active ingredient. PN (polynucleotide) is extracted from salmon DNA and is the component the clinic credits with supporting the skin's self-repair.
• Where it goes. The product is placed at many fine points within the skin of the chosen area, such as the forehead, the eye area, the cheeks, or the chin.
• What it aims to change. The clinic describes the intended effect as stronger elasticity, fewer visible wrinkles, improved texture, and regeneration of damaged or aging skin.
• How it differs from filler. Rejuran is not designed to add volume or reshape a contour; it works on the quality of the skin itself.
• Why it takes time. Because the aim is repair rather than an instant fill, the visible change develops over days to weeks and is built up across several sessions.

The Rejuran products the clinic names

Within this service, the clinic refers to three versions of the product. Which one is used is decided after the doctor has assessed your skin and the area to be treated.

Product	Clinic's stated focus	Typical consideration
Rejuran	Skin self-repair, elasticity, wrinkles, texture	General skin-quality concerns on the face
Rejuran HB	Adds a focus on hydration and volume	Skin that also feels dry or looks depleted
Rejuran Eye	Wrinkles and elasticity around the eyes	The thin, sensitive skin of the eye area

Patients sometimes arrive asking for a specific variant they have read about online. Only the three products above are listed by the clinic for this service, so it is worth raising any other name at the consultation rather than assuming it is available.

What the research says about polynucleotides

Polynucleotide injections are a relatively young treatment category, and the evidence is growing but still limited in size and quality. A 2024 systematic review of polynucleotides in aesthetic medicine found nine studies involving 219 patients; the reviewers reported encouraging results for wrinkles, texture, and elasticity, noted that side effects were mostly mild and short-lived, and called for larger, better-designed trials (PN systematic review, PMC). A later systematic review that looked only at randomized clinical trials of polynucleotides and the related polydeoxyribonucleotides identified seven trials with 183 participants, only some of them on skin rejuvenation rather than scars or wound healing, and reported favorable tolerability (RCT systematic review, PMC). Those are small numbers, so research supports polynucleotides as a reasonable option for skin quality without predicting what any one person will see.

Who Performs Rejuran Injection at Doctorpetit Clinic Hongdae

Dr. Chae-ho Lee
Medical Director at Doctorpetit Clinic Hongdae

Dr. Chae-ho Lee performs every Rejuran injection at Doctorpetit Clinic Hongdae himself; as Medical Director, he is also the sole physician on the team. Skin boosters and biostimulators are among his stated core specializations, and Rejuran is listed by name among his subspecialty techniques. He is a member of the Korean Society of Clinical Aesthetic Medicine. Because he is the sole doctor, the person who reviews your skin, history, and goals is also the person who chooses the product and places each injection.

Who Is a Good Candidate for Rejuran Injection?

Rejuran is usually considered when the concern is the condition of the skin rather than its volume or position. You may be a candidate if you have:

• Fine lines or wrinkles that you would like to soften without surgery.
• Skin that has lost firmness or elasticity with age.
• Dryness, dullness, or uneven texture that skincare alone has not improved.
• Skin that has become sensitive after laser treatments, a profile the clinic specifically mentions for Rejuran.
• Thin or crepey skin around the eyes, for which Rejuran Eye is designed.
• Realistic expectations of gradual change built over a series of sessions.

Rejuran may not be suitable, or may need to be postponed, if you have:

• An active skin infection at the planned treatment site.
• Significant inflammation of the skin in the area.
• A known allergy to any ingredient of the product.
• Certain medical conditions identified during the consultation.

If your main concern is hollowness, deep folds, or sagging, a different category of treatment may serve you better, and Dr. Lee will say so at the consultation.

What the consultation covers

The decision about Rejuran is made in person. Dr. Lee looks at your skin condition, the specific concerns you raise, the areas you want treated, and your goals, and uses that assessment to choose the Rejuran type and plan the number of sessions. He also asks about medications, allergies, earlier cosmetic procedures, and any skin conditions, because these affect whether an injection is appropriate on the day.

Common wishes among U.S. patients include natural-looking change rather than a dramatic difference, clear explanations in English, and confirmation that the product is genuine. Those are fair questions to bring to the consultation, along with how many sessions fit your travel dates. If you are unsure whether you need Rejuran at all, say so; the clinic's stated principle is to listen to each patient's concerns before recommending a plan.

What to Expect: Procedure, Recovery, and Results Timeline

Before your appointment

Tell the doctor about any medications you take, allergies, skin conditions, previous cosmetic treatments, and relevant medical history. You may be asked to avoid products or activities that could irritate the area beforehand; follow the specific instructions you receive. Do not stop a prescribed medicine on your own; any change should be agreed with the doctor who prescribed it.

How the treatment is carried out

1. Consultation. Dr. Lee examines your skin, discusses your goals, and confirms which Rejuran product suits the area.
2. Preparation. Your skin is cleansed, and each injection point is marked.
3. Numbing. Anesthetic cream is applied, and local anesthesia is also used for comfort.
4. Injection. The PN product is injected in small amounts into the targeted areas of skin.
5. Finish. The skin is gently cleaned and checked.
6. Aftercare. You receive straightforward post-treatment instructions before leaving.

The injection stage takes about 15 to 30 minutes, depending on the dosage and the size of the area. Brief stinging during the injections is common, and how much you feel varies by person and by area.

Recovery and results timeline

When	What to expect
Immediately	Daily activities can be resumed straight away.
Days 1–3	Mild redness, pinpoint bruising, tenderness, or swelling is common.
Days 1–3	Small raised marks at the injection points are expected; in the clinic's description, this embossing effect develops over about 2–3 days.
About 1 week to 1 month	The skin-quality effects typically begin to appear.
Over 3 sessions	Results build with a course of three treatments at 2–3-week intervals.
About 3–6 months	Typical duration of the effect, depending on individual skin condition.
Every 2–3 months	Maintenance treatments are recommended to sustain results.

The embossing effect varies between individuals, and some people notice it more than others. Plan any events where you want smooth-looking skin with those few days in mind.

Aftercare

Keep the treated skin clean and try not to touch, rub, or press on it more than necessary. Avoid activities that could irritate the treated skin for the period the clinic advises. If you develop anything unexpected, such as worsening pain or swelling or signs of infection, contact the clinic promptly, including after you return home.

After you fly home

Once you are back in the United States, the clinic remains reachable through its website contact form and by phone at +82-2-3144-7885. If something looks wrong in the days after treatment, get in touch and describe what you are seeing; for anything severe or rapidly worsening, seek local medical care first and let the clinic know afterward. Keeping a few photos of the treated area from the first days can help when you describe changes remotely.

Planning a trip to Seoul for Rejuran

Rejuran is an outpatient treatment without a prolonged recovery, so many international patients plan a short stay of around 2–3 days around the consultation and treatment. Flying may be possible soon afterward, but confirm the timing with the clinic, particularly if swelling or other temporary effects appear. The recommended course of three sessions 2–3 weeks apart means a full course usually involves either a longer stay or return visits, so it helps to map out the schedule before booking flights. Seoul opening times are 10:30–20:30 Monday through Friday and 10:30–17:00 at weekends (last registration 18:00 on weekdays, 15:00 at weekends), and the clinic does not open on the final Sunday of the month.

Combining Rejuran Injection with Other Treatments

The clinic does not publish a fixed combination protocol for Rejuran. Its list of alternative non-surgical skin-rejuvenation options includes other skin boosters, laser treatments, radiofrequency, and ultrasound-based treatments, and Dr. Lee can explain how these compare with Rejuran for your concern. Within the same specialty, the clinic also offers Hyaluronic Acid & Collagen Skin Boosters, P198 Exosome Healer / Exosome Skin Booster, and Melasma Brightening Injection. Whether anything should be paired with Rejuran, and in what order, is decided at the consultation.

Safety, Precision, and Clinic Standards

• Doctorpetit Clinic Hongdae has been on Korea's Ministry of Health and Welfare list of foreign-patient medical institutions since January 2023.
• The clinic states that it uses certified genuine products according to the indicated dosage.
• Every treatment plan follows a 1:1 consultation with the Medical Director.
• Dr. Chae-ho Lee selects the product and performs each injection himself.
• English consultation and interpretation support is available during the visit.

Possible side effects and risks

Common, temporary effects after Rejuran include redness, swelling, bruising, tenderness, and small raised injection marks. Rare complications such as infection or prolonged inflammation are possible, as with any injectable procedure. Allergic reactions can also occur. Discuss your individual risks with the doctor before treatment, and seek medical attention promptly for severe or worsening pain, spreading redness, or any change that worries you.

The Bottom Line

• Rejuran delivers salmon-DNA polynucleotide into the skin to support repair, elasticity, and texture.
• The clinic names three products: Rejuran, Rejuran HB, and Rejuran Eye.
• Dr. Chae-ho Lee, whose listed subspecialties include Rejuran, performs every treatment.
• Daily activities resume immediately, while temporary raised marks typically settle over a few days.
• Three sessions at 2–3-week intervals are recommended, with effects lasting about 3–6 months.

Frequently Asked Questions

Is Rejuran the same as a filler?
No. A filler is designed to add volume or shape a contour, while Rejuran works within the skin to support repair and improve elasticity and texture. It is chosen for skin-quality concerns rather than hollowness.

Does a Rejuran injection hurt?
Some discomfort or brief stinging can occur as the product is injected. The clinic uses anesthetic cream together with local anesthesia to keep the procedure comfortable. Sensitivity varies from person to person and between areas of the face.

Why does my skin look bumpy afterward?
The product is placed at many small points, so raised marks at those points are an expected part of the process. The clinic describes this embossing effect as developing over about 2–3 days, and how visible it is differs between individuals.

How soon will I notice a difference?
Effects typically appear within about one week to one month after treatment. Because the change develops gradually, results become more evident across a full course of sessions.

How many sessions do I need, and how long do results last?
Three treatments at 2–3-week intervals are recommended for the best results. The effect typically lasts about 3–6 months depending on your skin, and maintenance treatments every 2–3 months help sustain it.

What is the difference between Rejuran, Rejuran HB, and Rejuran Eye?
Rejuran addresses repair, elasticity, wrinkles, and texture. Rejuran HB adds a focus on hydration and volume, and Rejuran Eye is designed for the thin, sensitive skin around the eyes. Dr. Lee recommends one after examining you.

Will the doctor speak English with me?
English consultation and interpretation support is available for international patients. You can ask questions about the product, the session plan, and aftercare in English before anything is injected.

Can I fly home after Rejuran?
Because recovery is short, flying is often possible soon after treatment. Confirm the timing with the clinic if you notice swelling or other temporary effects.

Book a Consultation at Doctorpetit Clinic Hongdae

If you are considering Rejuran injection in Seoul, the starting point is a private consultation with Dr. Chae-ho Lee, who will look at your skin and tell you which Rejuran product suits it, or whether another option would serve you better. English interpretation is available throughout. You can walk there in moments from Hongik University Station Exit 1: the clinic occupies the 8th floor of the Wookdo Building, 151 Yanghwa-ro, in Mapo-gu. Request your appointment online, and look through the clinic's before-and-after gallery while you plan.

Disclaimer

Treatment suitability, expected results, recovery time, risks, and potential side effects vary by individual. The information provided is for general informational purposes and does not replace an in-person medical consultation. Patients should discuss their medical history, treatment goals, and individual circumstances with a qualified medical professional before undergoing treatment.

Sources & Further Reading

• PMC — The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review
• PMC — Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation: A Systematic Review of Randomized Clinical Trials